VITAMIN D, ACUTE RESPIRATORY INFECTIONS, AND COVID-19: THE CURSE OF SMALL-SIZE RANDOMISED TRIALS. A CRITICAL REVIEW WITH META-ANALYSIS OF RANDOMISED TRIALS.

Vitamin D, acute respiratory infections, and Covid-19: The curse of small-size randomised trials. A critical review with meta-analysis of randomised trials.

BackgroundRandomised trials conducted from 2006 to 2021 indicated that vitamin D supplementation (VDS) was able to prevent severe COVID-19 and acute respiratory infections (ARI).However, larger randomised trials published in 2022 did not confirm the health benefits of VDS in COVID-19 patients.ObjectiveTo examine through a systematic review with met

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Quantitative Prediction of Human Pharmacokinetics and Pharmacodynamics of CKD519, a Potent Inhibitor of Cholesteryl Ester Transfer Protein (CETP)

CKD519, a selective inhibitor of cholesteryl ester transfer protein(CETP), is undergoing development as an oral agent for the treatment of primary hypercholesterolemia and mixed hyperlipidemia.The aim of this study was to predict the appropriate efficacious dose of CKD519 for humans in terms of the inhibition of CETP activity by developing a CKD519

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Mood Symptoms and Chronic Fatigue Syndrome Due to Relapsing-Remitting Multiple Sclerosis Are Associated with Immune Activation and Aberrations in the Erythron

Background: Multiple sclerosis (MS) is a chronic autoimmune and neuroinflammatory disease of the central nervous system characterized by peripheral activation of immune-inflammatory pathways which culminate in neurotoxicity causing demyelination of central neurons.Nonetheless, the pathophysiology of relapsing-remitting MS (RRMS)-related chronic fat

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